THE ADDITION OF DOXAZOSIN TO THE TREATMENT REGIMEN OF PATIENTS WITH HYPERTENSION NOT ADEQUATELY CONTROLLED BY BETA-BLOCKERS

被引:24
作者
ENGLERT, RG [1 ]
BARLAGE, U [1 ]
机构
[1] CLIN RES PFIZER MACK,KARLSRUHE,GERMANY
关键词
D O I
10.1016/0002-8703(91)90864-E
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
When doxazosin was given to patients with hypertension not adequately controlled by beta-blockade, blood pressure was normalized in 94% of the 34 patients (blood pressure less-than-or-equal-to 140/85 mm Hg). This reduction in blood pressure was obtained with doxazosin in combination with metoprolol or oxprenolol at a mean final daily dose of 1.3 mg or pindolol or atenolol at 2.0 mg/day. Exercise-induced increase in systolic and diastolic blood pressure was also lower with combined-beta-blocker and doxazosin therapy than with beta-blocker alone. After 12 weeks of treatment, the combination of doxazosin and beta-blocker significantly reduced total serum cholesterol and triglyceride levels. All side effects were mild and only one patient was withdrawn from therapy.
引用
收藏
页码:311 / 316
页数:6
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