NEW LIGANDS FOR L-TYPE CA-2+ CHANNELS

被引：61

作者：

RAMPE, D ^{[1
]}

TRIGGLE, DJ ^{[1
]}

机构：

[1] SUNY BUFFALO,SCH PHARMACOL,BUFFALO,NY 14260

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1990年 / 11卷 / 03期

关键词：

(+)-PN 200-110; isopropyl-4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-5-methoxycarbonylpyridine-3-carboxylate; N-ω-aminohexyl-5-chloronaphthalenesulfonamide; W-7;

D O I：

10.1016/0165-6147(90)90196-F

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Although the clinically important categories of drug represented by verapamil, nifedipine and diltiazem are defined as acting at three major and discrete sites on the L class of voltage-dependent Ca2+ channel, it is likely that some new classes of drug modulate channel activity by acting at additional sites. David Rampe and David Triggle describe the actions of some of these new drugs, which may both offer improved therapeutic and side-effect profiles over existing agents and provide information to define further the structure and function of this channel class. These drugs may mimick the actions of endogenous ligand(s) and such ligands could provide new directions for Ca2+ channel drug structures. © 1990.

引用

页码：112 / 115

页数：4

共 39 条

[1] (+)-NIGULDIPINE BINDS WITH VERY HIGH-AFFINITY TO CA-2+ CHANNELS AND TO A SUBTYPE OF ALPHA-1-ADRENOCEPTORS [J].