THE STRUCTURE OF THE HUMAN GENE ENCODING PROTEIN GENE-PRODUCT 9.5 (PGP9.5), A NEURON-SPECIFIC UBIQUITIN C-TERMINAL HYDROLASE

被引：63

作者：

DAY, INM

HINKS, LJ

THOMPSON, RJ

机构：

来源：

BIOCHEMICAL JOURNAL | 1990年 / 268卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1042/bj2680521

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Database search using a bovine thymus ubiquitin C-terminal hydrolase sequence indicated 54% sequence identity with the abundant human neuron-specific protein gene product 9.5 (PGP9.5), which was then shown to posssess the same activity [Wilkinson, Lee, Deshpande, Duerksen-Hughes, Boss and Pohl (1989) Science 246, 670-673]. A yeast counterpart of the enzyme is also known. The human PGP9.5 gene, described here, spans 10 kb, contains nine exons and displays 5' features some common to many genes and some common with neurofilament neuron-specific enolase and Thy-1-antigen gene 5' regions.

引用

页码：521 / 524

页数：4

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