NUCLEOTIDE REGULATION OF VASOACTIVE-INTESTINAL-PEPTIDE BINDING TO BOVINE THYROID PLASMA-MEMBRANES

被引：6

作者：

CALVO, JR

MORALES, MF

MESA, JC

GOBERNA, R

机构：

[1] Department of Medical Biochemistry and Molecular Biology, School of Medicine, University of Sevilla, Sevilla, 4 41009, Avda. Sánchez Pizjuán

来源：

BIOSCIENCE REPORTS | 1990年 / 10卷 / 06期

关键词：

VASOACTIVE INTESTINAL PEPTIDE BINDING; THYROID PLASMA MEMBRANES; NUCLEOTIDE REGULATION;

D O I：

10.1007/BF01116612

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The specific binding of vasoactive intestinal peptide (VIP) to bovine thyroid plasma membranes is inhibited by guanine nucleotides. Guanosine 5'-triphosphate (GTP) and the non-hydrolyzable GTP analogs guanosine 5'-beta,gamma-imidotriphosphate (Gpp(NH)p) and guanosine 5'-O-(3-thiotriphosphate) (GTP-gamma-S) inhibited markedly the binding of VIP to its receptors. This inhibition was higher with GTP than with Gpp(NH)p and GTP-gamma-S and was due to an increase of the rate of dissociation of peptide bound to membranes. Other nucleotides did not show any effect.

引用

页码：519 / 525

页数：7

共 33 条

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