SUBCLINICAL DAMAGE TO THE NIGROSTRIATAL DOPAMINE SYSTEM BY MPTP AS A MODEL OF PRECLINICAL PARKINSONS-DISEASE - A REVIEW

被引：13

作者：

BURNS, RS

机构：

[1] Department of Neurology School of Medicine, Vanderbilt University, Nashville, Tennessee

来源：

ACTA NEUROLOGICA SCANDINAVICA | 1991年 / 84卷

关键词：

MPTP (1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE); PRIMATES; HUMANS; PARKINSONISM; ASYMPTOMATIC; NIGROSTRIATAL DOPAMINE SYSTEM;

D O I：

10.1111/j.1600-0404.1991.tb05017.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The study of subtle changes in motor and cognitive function after exposure to MPTP might serve as a guide to the very earliest stages of Parkinson's disease. Studies in nonhuman primates and man exposed to MPTP who remained asymptomatic or recovered completely are reviewed. The question of the relationship between the degree and extent of damage to the nigrostriatal dopamine system and changes in motor and cognitive (behavioral) function is addressed. What guidance they provide in the study of subclinical or preclinical Parkinson's disease is discussed.

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页码：29 / 36

页数：8

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