EFFECT OF A SINGLE DOSE OF DES-GLYCINAMIDE-[ARG8]VASOPRESSIN OR OXYTOCIN ON COGNITIVE-PROCESSES IN YOUNG HEALTHY-SUBJECTS

被引：57

作者：

BRUINS, J ^{[1
]}

HIJMAN, R ^{[1
]}

VANREE, JM ^{[1
]}

机构：

[1] RUDOLF MAGNUS INST PHARMACOL,DEPT PHARMACOL,3521 GD UTRECHT,NETHERLANDS

来源：

PEPTIDES | 1992年 / 13卷 / 03期

关键词：

DGAVP; OXYTOCIN; MEMORY; VIGILANCE; MOOD; GENDER; HEALTHY SUBJECTS;

D O I：

10.1016/0196-9781(92)90075-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A single dose of des-glycinamide-[Arg]vasopressin (DGAVP, 2 mg intranasal) or oxytocin (OXT, 20 IU intranasal) was given to female and male volunteers, respectively, in a placebo-controlled double-blind trial. Memory, vigilance, attention, and mood were tested starting 10 minutes after treatment. The DGAVP dose improved delayed recognition of abstract words when measured 1 week after treatment and reduced the intercept of a memory comparison task (Sternberg paradigm). A trend was present for DGAVP and OXT to affect learning, i.e., storage processes of verbal memory in an opposite way; DGAVP improved, while OXT attenuated initial storage and the rate of storage. No treatment effects on visual memory and vigilance were found. Of the mood measures, vigor was reduced immediately after treatment with OXT.

引用

页码：461 / 468

页数：8

共 41 条

[1]

[Anonymous], 1974, PSYCHOL SEX DIFFEREN

[2] INTRANASAL OXYTOCIN IN OBSESSIVE-COMPULSIVE DISORDER [J].

ANSSEAU, M ;

LEGROS, JJ ;

MORMONT, C ;

CERFONTAINE, JL ;

PAPART, P ;

GEENEN, V ;

ADAM, F ;

FRANCK, G .

PSYCHONEUROENDOCRINOLOGY, 1987, 12 (03) :231-236

[3] VASOPRESSIN ANALOG (DDAVP) IMPROVES MEMORY IN HUMAN MALES [J].

BECKWITH, BE ;

TILL, RE ;

SCHNEIDER, V .

PEPTIDES, 1984, 5 (04) :819-822

[4] VASOPRESSIN ANALOG INFLUENCES THE PERFORMANCE OF MALES ON A REACTION-TIME-TASK [J].

BECKWITH, BE ;

COUK, DI ;

TILL, TS .

PEPTIDES, 1983, 4 (05) :707-709

[5] VASOPRESSIN ANALOG (DDAVP) FACILITATES CONCEPT-LEARNING IN HUMAN MALES [J].

BECKWITH, BE ;

PETROS, T ;

KANAANBECKWITH, S ;

COUK, DI ;

HAUG, RJ .

PEPTIDES, 1982, 3 (04) :627-630

[6] OXYTOCIN, VASOPRESSIN AND MEMORY - OPPOSITE EFFECTS ON CONSOLIDATION AND RETRIEVAL PROCESSES [J].

BOHUS, B ;

KOVACS, GL ;

DEWIED, D .

BRAIN RESEARCH, 1978, 157 (02) :414-417

[7] INFORMATION-PROCESSING IN DEPRESSION AND ANXIETY [J].

BRAND, N ;

JOLLES, J .

PSYCHOLOGICAL MEDICINE, 1987, 17 (01) :145-153

[8]

BRAND N, 1987, MEMORY INFORMATION P

[9] INFLUENCE OF DESGLYCINAMIDE-(ARG8) VASOPRESSIN ON MEMORY IN HEALTHY-SUBJECTS [J].

BRUINS, J ;

KUMAR, A ;

SCHNEIDERHELMERT, D .

NEUROPSYCHOBIOLOGY, 1990, 23 (02) :82-88

[10] SPONTANEOUS REMEMBERING AFTER RECALL FAILURE [J].

BUSCHKE, H .

SCIENCE, 1974, 184 (4136) :579-581

← 1 2 3 4 5 →