A METHOD FOR THE STUDY OF THE EFFECT OF BARRIER CREAMS AND PROTECTIVE GLOVES ON THE PERCUTANEOUS-ABSORPTION OF SOLVENTS

Solvents [benzene, 1,1,-Trichloroethane and toluene] were administered into closed skin depots on guinea pigs and the resulting blood concentrations were measured in samples repeatedly obtained via a catheter in the carotid artery. The exposure areas were protected with rubber or plastic glove membranes or with barrier creams rubbed into the skin before administration of the solvents. Results from experiments with 2 solvents, various gloves and barrier creams with claimed protective effects are presented. This animal model seems suitable for screening purposes and capable of differentiating between various commercial products.