PROPERDIN - APPROACHING 4 DECADES OF RESEARCH

被引：21

作者：

MAVES, KK

WEILER, JM

机构：

[1] UNIV IOWA, COLL MED, IOWA CITY, IA 52242 USA

[2] VET ADM MED CTR, DEPT INTERNAL MED, IOWA CITY, IA 52240 USA

来源：

IMMUNOLOGIC RESEARCH | 1993年 / 12卷 / 03期

关键词：

PROPERDIN; C3; CONVERTASE; ALTERNATIVE PATHWAY; PILLEMER; MENINGOCOCCI;

D O I：

10.1007/BF02918255

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Properdin plays a key role in the alternative pathway by stabilizing the C3 convertase. This review chronicles the evolution of our knowledge of the structure and function of properdin over the 40 years since its discovery. The story begins with the first description of properdin and the controversy that ensued over its existence. Then, this review describes: the rediscovery and acceptance of properdin and the alternative pathway as important components of natural immunity; properdin structure and molecular sequence; speculations on the significance of sequence similarities to thrombospondin and other proteins, and properdin biosynthesis. Finally, this review characterizes properdin deficiency. Properdin does indeed appear to play an important role in homeostasis.

引用

页码：233 / 243

页数：11

共 77 条

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