SYNTHESES OF NOVEL NONREDUCING-SUGAR SUBUNIT ANALOGS OF LIPID-A CARRYING 2-ACYLOXYTETRADECANOYL AND 2-HYDROXYACYL GROUPS OF DIFFERENT CARBON-CHAIN LENGTH

被引：3

作者：

OGAWA, Y

WAKIDA, M

ISHIDA, H

KISO, M

HASEGAWA, A

机构：

[1] Department of Applied Bioorganic Chemistrv, Gifu University

来源：

JOURNAL OF CARBOHYDRATE CHEMISTRY | 1994年 / 13卷 / 03期

关键词：

D O I：

10.1080/07328309408009204

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To investigate the biological influence of the 2-(acyloxy)tetradecanoyl and 2-hydroxyacyl groups in the nonreducing-sugar subunit analogs of lipid A, a novel series of 3-O-[(2RS)-2-acyloxytetradecanoyl]-2-deoxy-2[(2RS)-2-hydroxytetradecanamido]-4-O-phosphono-D-glucoses (10a-d), 3-O- [(2RS)-2-acyloxytetradecanoyl]-2-deoxy-2-[(3R)-3-hydroxytetradecanamido]-4-O-phosphono-D-glucoses (19a-d), and 2-deoxy-2-[(2RS)-2-hydroxyacyl]amino-4-O-phosphono-3-O- [(3R)-3-tetradecanoyloyloxytetradecanoyl]-D-glucbses (23e-h) were systematically synthesized.

引用

收藏

页码：433 / 446

页数：14

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