ABNORMAL FIBROBLAST MICROTUBULE RESPONSE IN FAMILIAL ALZHEIMER-DISEASE

被引：3

作者：

MATSUYAMA, SS

JARVIK, LF

机构：

[1] W LOS ANGELES VA MED CTR,PSYCHOGERIATR UNIT & LAB,BRENTWOOD DIV,LOS ANGELES,CA

[2] UNIV CALIF LOS ANGELES,INST NEUROPSYCHIAT,DEPT PSYCHIAT & BIOBEHAV SCI,LOS ANGELES,CA 90024

来源：

AGE | 1993年 / 16卷 / 04期

关键词：

D O I：

10.1007/BF02434992

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

There is increasing evidence that cytoskeletal changes, in particular perturbation of the microtubule (MT) system, play a role in the pathogenesis of Alzheimer disease (AD). The reappearance of the cytoplasmic MT network following treatment with the MT disrupting agent colchicine was investigated in commercially available (Human Genetic Cell Repository, Camden, NJ) fibroblasts derived from 11 patients with familial AD and 11 controls. The AD cells revealed a significant delay in the reappearance of that network following release from treatment with colchicine. Further research with larger samples is needed to determine the sensitivity and specificity of this finding for AD as well as research into the underlying bases for the observed differences.

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页码：152 / 158

页数：7

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