DIRECT ENANTIOMERIC RESOLUTION OF IBUPROFEN AND FLURBIPROFEN BY PACKED-COLUMN SFC

被引：49

作者：

WILSON, WH

机构：

[1] Hewlett-Packard Co, Wilmington, Delaware

来源：

CHIRALITY | 1994年 / 6卷 / 03期

关键词：

SUPERCRITICAL FLUID CHROMATOGRAPHY; CHIRAL SEPARATION; NSAIDS; IBUPROFEN;

D O I：

10.1002/chir.530060310

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Packed column SFC is used to resolve the enantiomers of two nonsteroidal antiinflammatories. A Chiralpak AD column is used with a binary mobile phase of carbon dioxide/methanol to achieve resolution. The effects of composition, pressure, temperature, and flow on ibuprofen enantiomer separation are examined. In this instance, temperature affords the greatest change in resolution followed by pressure and composition. Baseline resolution of ibuprofen is achieved in less than 7 min and flurbiprofen is baseline resolved in less than 4 min. (C) 1994 Wiley-Liss, Inc.

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页码：216 / 219

页数：4

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