T-CELL RECEPTOR V-BETA REPERTOIRES OF ANGIOIMMUNOBLASTIC LYMPHADENOPATHY-LIKE T-CELL LYMPHOMA

被引：8

作者：

ARAKI, A

TANIGUCHI, M

MIKATA, A

机构：

[1] First Department of Pathology, Center for Biomedical Science, Chiba University School of Medicine, Inohana, Chiba

[2] Division of Molecular Immunology, Center for Biomedical Science, Chiba University School of Medicine, Inohana, Chiba

来源：

LEUKEMIA & LYMPHOMA | 1994年 / 16卷 / 1-2期

关键词：

ANGIOIMMUNOBLASTIC LYMPHADENOPATHY-LIKE T CELL LYMPHOMA; V-BETA REPERTOIRE; POLYMERASE CHAIN REACTION;

D O I：

10.3109/10428199409114150

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To elucidate the pathogenesis of angioimmunoblastic lymphadenopathy-like T cell lymphoma (AILD-T) we investigated the T cell receptor V beta gene repertoires of four AILD-Ts and compared them with those of other histological types of lymphomas and three cases with reactive disorders. All lymphoma patients had rearrangement bands detected by Southern blot analysis. Only 1 of the 4 cases of AILD-T showed a single predominant usage of V beta 20 gene by PCR with 20 different V beta specific primers and the others had repertoires somewhat restricted but similar to reactive lesions. Subsequent sequencing of this PCR product revealed that only 2 of 7 clones were identical. These results suggest the monoclonal malignant cells in AILD-T are scant and that the infiltrating T cells show a reactive pattern. In the only AILD-T case with a single dominant V beta usage, the relationships of this repertoire and lymphoma cells seems to be of some consequence.

引用

页码：135 / 140

页数：6

共 26 条

[1]

Shimoyama M., Minato K., Saito H., Takenaka T., Watanabe S., Nagatani T., Naruto M., Immunoblastic lymphadenopathy (IBL)-like T-cell lymphoma, Jpn. J. Clin. Oncol., 9, Suppl., pp. 347-356, (1979)

[2]

Frizzera G., Moran E.M., Rappaport H., Angio-immunoblastic lymphadenopathy with dysproteinemia, Lancet, 1, pp. 1070-1073, (1974)

[3]

Lukes R.J., Tindle B.H., Immunoblastic lymphadenopathy: A hyperimmune entity resembling Hodgkin's disease, N. Engl. J. Med., 292, pp. 1-8, (1975)

[4]

Fisher R.I., Jaffe E.S., Braylan R.C., Anderson J.C., Tan H.K., Immunoblastic lymphadenopathy: Evolution into a malignant lymphoma with plasmacytoid features, Am. J. Med., 61, pp. 553-559, (1976)

[5]

Nathwani B.N., Rappaport H., Moran E.M., Pangalis G.A., Kim H., Malignant lymphoma arising in angioimmunoblastic lymphadenopathy, Cancer, 41, pp. 578-606, (1978)

[6]

Lukes R.J., Tindle B.H., Immunoblastic lymphadenopathy: A prelymphomatous state of immunoblastic sarcoma, Cancer Res., 64, pp. 241-246, (1978)

[7]

Weiss L.M., Strickler J.G., Dorfman R.F., Horning S.J., Wamke R.A., Sklar J., Clonal T cell populations in the angioimmunoblastic lymphadenopathy and angioimmunoblastic lymphadenopathy-like lymphoma, Am. J. Pathol., 122, pp. 392-397, (1986)

[8]

Griesser H., Feller A., Lennert K., Minden M., Mak T.W., Rearrangement of the B chain of the T cell antigen receptor and immunoglobulin genes in lymphoproliferative disorders, J. Clin. Invest., 78, pp. 1179-1184, (1986)

[9]

Bahler D.W., Berry G., Oksenberg J., Wamke R.A., Levy R., Diversity of T-cell antigen receptor variable genes used by mycosis fungoides cells, Am. J. Pathol., 140, pp. 1-8, (1992)

[10]

Jack A.S., Boylston A.W., Carrel S., Grigor I., Cutaneous T-cell lymphoma cells employ a restricted change of T-cell antigen receptor variable region genes, Am. J. Pathol., 136, pp. 17-21, (1990)

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