REDUCED ADENOSINE 3',5'-CYCLIC-MONOPHOSPHATE LEVELS IN PATIENTS WITH REVERSIBLE OBSTRUCTIVE AIRWAYS DISEASE

被引：18

作者：

KRZANOWSKI, JJ ^{[1
]}

POLSON, JB ^{[1
]}

GOLDMAN, AL ^{[1
]}

EBEL, TA ^{[1
]}

SZENTIVANYI, A ^{[1
]}

机构：

[1] UNIV S FLORIDA,COLL MED,DEPT INTERNAL MED,PULM DIS SECT,TAMPA,FL 33612

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1979年 / 6卷 / 01期

关键词：

adenosine; 3′; 5′‐cyclic monophosphate; cyclic AMP; cyclic GMP; guanosine; human lung;

D O I：

10.1111/j.1440-1681.1979.tb00013.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Patients were grouped into categories of ‘no airways disease’, ‘obstructive airways disease without response to bronchodilator’ and ‘obstructive airways disease with bronchodilator responsiveness’. 2. Cyclic nucleotides were assayed in specimens of lung tissue that were excised during surgery. 3. Reduced levels of adenosine 3′,5′‐cyclic monophosphate (cyclic AMP) were found in pulmonary tissue obtained from patients with reversible obstructive airways disease, lending support to the β‐adrenergic theory of asthma. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：111 / 115

页数：5

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