BETA-ADRENERGIC BLOCKING AGENTS .4. VARIATION OF 2-NAPHTHYL GROUP OF PRONETHALOL [2-ISOPROPYLAMINO-1-(2-NAPHTHYL)ETHONOL]

被引：14

作者：

HOWE, R

MCLOUGHLIN, BJ

RAO, BS

SMITH, LH

CHODNEKAR, MS

机构：

[1] Imperial Chemical Industries Ltd., Pharmaceuticals Division, Macclesfield, Cheshire, Alderley Park

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1969年 / 12卷 / 03期

关键词：

D O I：

10.1021/jm00303a027

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In attempts to improve the potency of the adrenergic (β-receptor antagonist pronethalol [2-isopropylamino-1- (2-naphthyl)ethanol] the 2-naphthyl group has been replaced by, for example, 1-naphthyl, tetrahydro-2-naphthyl, 5-indanyl, and various tricarbocyclic groups. Analogs have also been made with substituents other than i-Pr on N. Structure-activity relationships are discussed. Several of the compounds described have the same level of potency as pronethalol. © 1969, American Chemical Society. All rights reserved.

引用

页码：452 / +

页数：1

共 21 条

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