PERIPHERAL-BLOOD T-CELL ACTIVATION AFTER RADIOIODINE TREATMENT FOR GRAVES-DISEASE

被引:22
作者
TENG, WP
STARK, R
MUNRO, AJ
YOUNG, SM
BORYSIEWICZ, LK
WEETMAN, AP
机构
[1] UNIV CAMBRIDGE,ADDENBROOKES HOSP,SCH CLIN,DEPT MED,LEVEL 5,CAMBRIDGE CB2 2QQ,ENGLAND
[2] HAMMERSMITH HOSP,DEPT CLIN ONCOL,LONDON W12 0HS,ENGLAND
[3] CENT MIDDLESEX HOSP,DEPT MED,LONDON NW10 7NS,ENGLAND
来源
ACTA ENDOCRINOLOGICA | 1990年 / 122卷 / 02期
基金
英国惠康基金;
关键词
D O I
10.1530/acta.0.1220233
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Radioiodine therapy for Graves' thyrotoxicosis produces a rise in thyroid autoantibodies in the first three months after treatment, but little is known of its effects on T cells. We have therefore followed the changes in T cell subsets in sequential samples from 23 patients with Graves' disease treated with radioiodine, using dual-colour flow cytometry. In the first month after treatment there was a significant rise in activated T cells, identified by the markers HLA-DR (la) and CDw26/Ta1 (p < 0.025 in both cases). CD45RO-positive T cells, which are the primed population containing memory cells, also increased (p < 0.025), but there was no change in CD45R-positive, resting T cells or in the CD4 to CD8 (helper to cytotoxic/suppressor) ratio. Vicia villosa-binding T cells, containing the contrasuppressor population, showed a more variable response, but the trend was to an overall increase from pre-treatment values (p < 0.025). The changes did not appear to be related to antithyroid drug treatment, since they were seen irrespective of whether patients continued such therapy. These results suggest that T cell activation and enhanced contrasuppressor activity may in part be responsible for the rise in autoantibodies after radioiodine. The T cell changes could also contribute to the worsening of ophthalmopathy seen in some radioiodine-treated patients.
引用
收藏
页码:233 / 240
页数:8
相关论文
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