HYDROXYUREA INHIBITS ODC INDUCTION, BUT NOT THE G1 TO S-PHASE TRANSITION

被引：16

作者：

CRESS, AE ^{[1
]}

GERNER, EW ^{[1
]}

机构：

[1] UNIV ARIZONA,ARIZONA HLTH SCI CTR,DEPT RADIOL RADIAT ONCOL,TUCSON,AZ 85724

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 87卷 / 03期

关键词：

D O I：

10.1016/0006-291X(79)92025-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chinese hamster ovary cells, selected in mitosis and plated into medium containing hydroxyurea, can progress through G1 and enter S phase although bulk DNA synthesis is prevented. As the cells progress through G1 in the presence of hydroxyurea, ornithine decarboxylase activity remains low while general protein synthesis appears unaffected. After hydroxyurea is removed, ornithine decarboxylase activity increases, but only after approximately 20% of the DNA has been replicated. These results suggest that ornithine decarboxylase induction is not essential for cellular progression into S phase but is required for the completion of DNA synthesis. © 1979.

引用

页码：773 / 780

页数：8

共 26 条

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