INHIBITORY EFFECTS OF VANADIUM PENTOXIDE ON RESPIRATION OF RAT-LIVER MITOCHONDRIA

被引：20

作者：

ZYCHLINSKI, L

BYCZKOWSKI, JZ

机构：

[1] MED ACAD GDANSK,DEPT TOXICOL,GDANSK,POLAND

[2] UNIV S FLORIDA,COLL PUBL HLTH,FLORIDA TOXICOL RES CTR,TAMPA,FL 33612

来源：

ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY | 1990年 / 19卷 / 01期

关键词：

D O I：

10.1007/BF01059822

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The bioenergetic functions of liver mitochondria were studied following the acute and chronic exposure of rats to vanadium pentoxide via respiratory tract. The mitochondrial respiration with glutamate or succinate as substrate was inhibited significantly when compared to the control animals. No inhibition was found with ascorbate. The same effects were observed in vitro. Vanadium (V) was responsible for these inhibitory effects. It is postulated that significant amounts of vanadate are accumulated in the intermembrane space of liver mitochondria of the exposed rats. The process of "detoxification" by reduction of vanadate in the tissue may be insufficient to prevent the deleterious action of this compound on liver mitochondria. © 1990 Springer-Verlag New York Inc.

引用

页码：138 / 142

页数：5

共 26 条

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