IMMUNOGLOBULIN ISOTYPE DISTRIBUTION OF LOCALLY PRODUCED AUTOANTIBODIES TO COLLAGEN TYPE-I IN ADULT PERIODONTITIS - RELATIONSHIP TO PERIODONTAL TREATMENT

被引:28
作者
JONSSON, R
PITTS, A
LUE, C
GAY, S
MESTECKY, J
机构
[1] UNIV BERGEN,BROEGELMANN RES LAB MICROBIOL,ARMAUER HANSEN BLDG,N-5021 BERGEN,NORWAY
[2] UNIV ALABAMA,DEPT MICROBIOL,BIRMINGHAM,AL 35294
[3] UNIV ALABAMA,DEPT MED,BIRMINGHAM,AL 35294
[4] UNIV ALABAMA,ORAL BIOL RES CTR,BIRMINGHAM,AL 35294
关键词
CHRONIC INFLAMMATORY PERIODONTAL DISEASE; COLLAGEN; LYMPHOCYTES-B; AUTOANTIBODIES;
D O I
10.1111/j.1600-051X.1991.tb00113.x
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Production of antibodies to collagen type I was analyzed by means of an enzyme-linked immunospot (ELISPOT) assay in patients with chronic adult periodontitis (AP) before and after periodontal hygiene treatment. Anti-collagen type I antibody-secreting cells were found among mononuclear cells enzymatically eluted from inflamed gingiva in 9 of 15 patients with untreated AP and in 4 of 14 hygiene-treated patients with a varied isotype distribution. A notably high prevalence of IgG and IgM isotypes was observed for the anti-collagen antibodies in untreated patients. With wide variation, chronic AP was characterized by a high frequency of spontaneous IgG and low numbers of IgA and IgM-producing cells. Periodontal hygiene treatment significantly reduced the number of IgA and IgM-secreting cells. Although AP is not an autoimmune disease in the accepted sense, our results indicate that local autoimmune reactions to collagen type I are common in untreated AP, implying an interplay between periodontal infection and autoimmunity.
引用
收藏
页码:703 / 707
页数:5
相关论文
共 20 条
[1]   SPONTANEOUSLY PROLIFERATING HUMAN LYMPHOCYTES-B MAKE AUTOANTIBODIES [J].
ALLAWAY, GP ;
SRINIVASAPPA, J ;
MILLER, FW ;
PRABHAKAR, BS ;
NOTKINS, AL .
JOURNAL OF INFECTIOUS DISEASES, 1988, 157 (05) :968-972
[2]  
AMER A, 1987, J CLIN LAB IMMUNOL, V24, P183
[3]   A NOVEL 2 COLOR ELISPOT ASSAY .1. SIMULTANEOUS DETECTION OF DISTINCT TYPES OF ANTIBODY-SECRETING CELLS [J].
CZERKINSKY, C ;
MOLDOVEANU, Z ;
MESTECKY, J ;
NILSSON, LA ;
OUCHTERLONY, O .
JOURNAL OF IMMUNOLOGICAL METHODS, 1988, 115 (01) :31-37
[4]   A SOLID-PHASE ENZYME-LINKED IMMUNOSPOT (ELISPOT) ASSAY FOR ENUMERATION OF SPECIFIC ANTIBODY-SECRETING CELLS [J].
CZERKINSKY, CC ;
NILSSON, LA ;
NYGREN, H ;
OUCHTERLONY, O ;
TARKOWSKI, A .
JOURNAL OF IMMUNOLOGICAL METHODS, 1983, 65 (1-2) :109-121
[5]   AN ENZYMATIC METHOD FOR PREPARATION OF DISSOCIATED MURINE PEYERS PATCH CELLS ENRICHED FOR MACROPHAGES [J].
FRANGAKIS, MV ;
KOOPMAN, WJ ;
KIYONO, H ;
MICHALEK, SM ;
MCGHEE, JR .
JOURNAL OF IMMUNOLOGICAL METHODS, 1982, 48 (01) :33-44
[6]   ANTIBODY TO COLLAGEN TYPE-I IN PERIODONTAL-DISEASE [J].
FTIS, A ;
SINGH, G ;
DOLBY, AE .
JOURNAL OF PERIODONTOLOGY, 1986, 57 (11) :693-698
[7]   AUTOANTIBODIES AND THE PHYSIOLOGICAL-ROLE OF IMMUNOGLOBULINS [J].
GRABAR, P .
IMMUNOLOGY TODAY, 1983, 4 (12) :337-340
[8]   AUTOIMMUNITY TO COLLAGEN IN ADULT PERIODONTAL-DISEASE [J].
HIRSCH, HZ ;
TARKOWSKI, A ;
MILLER, EJ ;
GAY, S ;
KOOPMAN, WJ ;
MESTECKY, J .
JOURNAL OF ORAL PATHOLOGY & MEDICINE, 1988, 17 (9-10) :456-459
[9]   INSITU CHARACTERIZATION OF MONONUCLEAR-CELLS IN HUMAN CHRONIC MARGINAL PERIODONTITIS USING MONOCLONAL-ANTIBODIES [J].
JOHANNESSEN, AC ;
NILSEN, R ;
KNUDSEN, GE ;
KRISTOFFERSEN, T .
JOURNAL OF PERIODONTAL RESEARCH, 1986, 21 (02) :113-127
[10]   IMMUNOGLOBULIN BEARING LYMPHOCYTES AND PLASMA-CELLS IN HUMAN PERIODONTAL-DISEASE [J].
MACKLER, BF ;
FROSTAD, KB ;
ROBERTSON, PB ;
LEVY, BM .
JOURNAL OF PERIODONTAL RESEARCH, 1977, 12 (01) :37-45