BRAIN IMPLANTS IN MAN DO NOT BREAK DOWN THE BLOOD-BRAIN-BARRIER TO DOPAMINE AND DOMPERIDONE

被引：4

作者：

CLOUGH, CG ^{[1
]}

HITCHCOCK, ER ^{[1
]}

HUGHES, RC ^{[1
]}

HENDERSON, BT ^{[1
]}

KENNY, BG ^{[1
]}

机构：

[1] UNIV BIRMINGHAM,MIDLAND CTR NEUROSURG & NEUROL,DEPT NEUROSURG,HOLLY LANE,SMETHWICK,WARLEY B67 7JX,W MIDLANDS,ENGLAND

来源：

BRAIN RESEARCH | 1990年 / 536卷 / 1-2期

关键词：

PARKINSONS DISEASE; BLOOD-BRAIN BARRIER; NEURAL TRANSPLANTATION;

D O I：

10.1016/0006-8993(90)90042-A

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have evaluated the blood-brain barrier (BBB) in 8 Parkinsonian patients before and after stereotactic implantation of foetal mesencephalon (STIM) and one patient with an adrenal medullary implant. Parenteral administration of dopamine did not reverse Parkinsonism pre-operatively or at 5 days 1, 2, 3, 4 months and one year post-operatively. Apomorphine and domperidone reversed Parkinsonism and produced dyskinesia in all patients pre- and post-operatively. We conclude that the BBB remains intact to dopamine following implantation.

引用

页码：318 / &