USE OF HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY TO MONITOR STABILITY OF TETRACYCLINE AND CHLORTETRACYCLINE IN SUSCEPTIBILITY DETERMINATIONS

被引：6

作者：

RAY, A

NEWTON, V

机构：

[1] Division of Chemistry, National Biol. Standards Inst., Potters Bar, Herts EN6 3QG, Blanche Lane, South Mimms

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1991年 / 35卷 / 06期

关键词：

D O I：

10.1128/AAC.35.6.1264

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Trypticase soy broth and nutrient broth were used in the antimicrobial susceptibility testing of tetracycline and chlortetracycline with Bacillus subtilis. The stability of the antibiotics in both media at an incubation temperature of 37-degrees-C was monitored by high-performance liquid chromatography. It was found that Trypticase soy broth has limited application in susceptibility testing for the tetracycline congeners tested and that chlortetracycline is more unstable than tetracycline.

引用

页码：1264 / 1266

页数：3

共 9 条

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