ANTINEOPLASTIC AGENTS .196. ISOLATION AND STRUCTURE OF CYTOSTATIC STEROIDAL SAPONINS FROM THE AFRICAN MEDICINAL PLANT BALANITES-AEGYPTICA

被引：44

作者：

PETTIT, GR

DOUBEK, DL

HERALD, DL

NUMATA, A

TAKAHASI, C

FUJIKI, R

MIYAMOTO, T

机构：

[1] ARIZONA STATE UNIV,DEPT CHEM,TEMPE,AZ 85287

[2] OSAKA UNIV PHARMACEUT SCI,MATSUBARA,OSAKA 580,JAPAN

来源：

JOURNAL OF NATURAL PRODUCTS | 1991年 / 54卷 / 06期

关键词：

D O I：

10.1021/np50078a002

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioactivity-guided separation of a CH2Cl2/MeOH extract of Balanites aegyptica afforded four new cytostatic saponins, named balanitins 4 [1], 5 [2], 6 [3], and 7 [4]. On the basis of enzymatic hydrolyses and glycosidation nmr chemical shifts employing the peracetates, structures 1-4 were established as yamogenin 3-beta-O-beta-D-glucopyranosyl-(1-bar-arrow-pointing-right 3)-beta-D-glucopyranosyl-(1 barr-arrow-pointing-right 4)-[alpha-L-rhamnopyranosyl-(1 barr-arrow-pointing-right 2)]-beta-D-glucopyranoside [1], yamogenin 3-beta-O-alpha-L-rhamnopyranosyl-(1 barr-arrow-pointing-right 3)-beta-D-glucopyranosyl-(1 barr-arrow-pointing-right)-[alpha-L-rhamnopyranosyl-(1 barr-arrow-pointing-right)]-beta-D-glucopyranoside [2], yamogenin 3-beta-O-beta-D-glucopyranosyl-(1 barr-arrow-pointing-right 4)-[alpha-L-rhamnopyranosyl-(1 barr-arrow-pointing-right 2)]beta-D-glu copyranoside [3], and diosgenin 3-beta-O-beta-D-xylpyranosyl-(1 barr-arrow-pointing-right-3)-beta-D-glucopranosyl-(1 barr-arrow-pointing-right 4)-[alpha-L-rhamnopyranosyl-(1 barr-arrow-pointing -right 2)]-beta-D-glucopyranoside [4].

引用

页码：1491 / 1502

页数：12

共 22 条

[1] C-13 NMR SPECTRAL INVESTIGATIONS .10. C-13 NMR-SPECTROSCOPY OF STEROIDAL SAPOGENINS AND STEROIDAL SAPONINS [J].

AGRAWAL, PK ;

JAIN, DC ;

GUPTA, RK ;

THAKUR, RS .

PHYTOCHEMISTRY, 1985, 24 (11) :2479-2496

[2]

BOCK K, 1973, TETRAHEDRON LETT, P1037

[3]

DUKE J, 1983, MED PLANTS BIBLE, P28

[4]

GERAN RI, 1972, CANC CHEMOTHER REP, V3, P1

[5]

KASAI R, 1977, TETRAHEDRON LETT, P175

[6] C-13 NMR-STUDY OF ALPHA-ANOMERIC AND BETA-ANOMERIC PAIRS OF D-MANNOPYRANOSIDES AND L-RHAMNOPYRANOSIDES [J].

KASAI, R ;

OKIHARA, M ;

ASAKAWA, J ;

MIZUTANI, K ;

TANAKA, O .

TETRAHEDRON, 1979, 35 (11) :1427-1432

[7]

KAZUKO Y, 1987, YAKUGAKU ZASSHI, V1107, P361

[8]

KITAGAWA I, 1975, CHEM PHARM BULL, V23, P2268

[9]

KITAGAWA I, 1976, CHEM PHARM BULL, V24, P275

[10]

KITAGAWA I, 1978, CHEM PHARM BULL, V26, P3722

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