CARBAMAZEPINE VERSUS LITHIUM IN THE PROPHYLAXIS OF BIPOLAR AFFECTIVE-DISORDER

被引:120
作者
COXHEAD, N
SILVERSTONE, T
COOKSON, J
机构
[1] ST BARTHOLOMEWS HOSP & MED COLL,ACAD UNIT HUMAN PSYCHOPHARMACOL,LONDON EC1A 7BE,ENGLAND
[2] ROYAL LONDON HOSP,COLL MED,LONDON,ENGLAND
关键词
CARBAMAZEPINE; LITHIUM; PROPHYLAXIS; AFFECTIVE DISORDER; WEIGHT GAIN;
D O I
10.1111/j.1600-0447.1992.tb01453.x
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
A 12-month double-blind trial of carbamazepine vs lithium, given as sole treatment for the prophylaxis of bipolar affective disorder, was carried out in 31 patients. All were previously stable on lithium; 15 were switched over to carbamazepine and 16 remained on lithium. Although the overall relapse rate was similar in the 2 groups (6 on carbamazepine, 8 on lithium), nearly all the relapses in carbamazepine occurred in the first month, probably precipitated by lithium withdrawal. Two patients on carbamazepine developed a rash and were withdrawn. More side effects were noted during the early stages on carbamazepine. Patients on lithium tended to gain weight (+4 kg) compared with carbamazepine (-3.1 kg). It is concluded that carbamazepine is as effective as lithium in the prophylaxis of bipolar affective disorder; changeover from lithium to carbamazepine should be done slowly.
引用
收藏
页码:114 / 118
页数:5
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