2.1-ANGSTROM RESOLUTION REFINED STRUCTURE OF A TATA BOX-BINDING PROTEIN (TBP)

被引:105
作者
NIKOLOV, DB [1 ]
BURLEY, SK [1 ]
机构
[1] ROCKEFELLER UNIV, HOWARD HUGHES MED INST, MOLEC BIOPHYS LAB, NEW YORK, NY 10021 USA
来源
NATURE STRUCTURAL BIOLOGY | 1994年 / 1卷 / 09期
关键词
D O I
10.1038/nsb0994-621
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The three-dimensional structure of a TATA box-binding protein (TBP2) from Arabidopsis thaliana has keen refined at 2.1 Angstrom resolution. TBPs are general eukaryotic transcription factors that participate in initiation of RNA synthesis by all three eukaryotic RNA polymerases. The carboxy-terminal portion of TBP is a unique DNA-binding motif/protein fold, adopting a highly symmetric alpha/beta structure that resembles a molecular saddle with two stirrup-like loops. A ten-stranded, antiparallel beta-sheet provides a concave surface for recognizing class II nuclear gene promoters, while the four amphipathic a-helices on the convex surface are available for interaction with other transcription factors. The myriad interactions of TBP2 with components of the transcription machinery are discussed.
引用
收藏
页码:621 / 637
页数:17
相关论文
共 104 条
  • [1] WHEAT TFIID TATA BINDING-PROTEIN
    APSIT, V
    FREEBERG, JA
    CHASE, MR
    DAVIS, EA
    ACKERMAN, S
    [J]. NUCLEIC ACIDS RESEARCH, 1993, 21 (06) : 1494 - 1494
  • [2] BERK AJ, 1992, TRANSCRIPTIONAL REGU, P727
  • [3] A METHOD TO IDENTIFY PROTEIN SEQUENCES THAT FOLD INTO A KNOWN 3-DIMENSIONAL STRUCTURE
    BOWIE, JU
    LUTHY, R
    EISENBERG, D
    [J]. SCIENCE, 1991, 253 (5016) : 164 - 170
  • [4] BRUNGER AT, 1992, XPLOR MANUAL
  • [5] A SUPPRESSOR OF TBP MUTATIONS ENCODES AN RNA POLYMERASE-III TRANSCRIPTION FACTOR WITH HOMOLOGY TO TFIIB
    BURATOWSKI, S
    ZHOU, H
    [J]. CELL, 1992, 71 (02) : 221 - 230
  • [6] TRANSCRIPTION FACTOR-IID MUTANTS DEFECTIVE FOR INTERACTION WITH TRANSCRIPTION FACTOR-IIA
    BURATOWSKI, S
    ZHOU, H
    [J]. SCIENCE, 1992, 255 (5048) : 1130 - 1132
  • [7] 5 INTERMEDIATE COMPLEXES IN TRANSCRIPTION INITIATION BY RNA POLYMERASE-II
    BURATOWSKI, S
    HAHN, S
    GUARENTE, L
    SHARP, PA
    [J]. CELL, 1989, 56 (04) : 549 - 561
  • [8] BURATOWSKI S, 1992, TRANSCRIPTIONAL REGU, P227
  • [9] FUNCTIONAL AND BIOCHEMICAL INTERACTION OF THE HTLV-I TAX1 TRANSACTIVATOR WITH TBP
    CARON, C
    ROUSSET, R
    BERAUD, C
    MONCOLLIN, V
    EGLY, JM
    JALINOT, P
    [J]. EMBO JOURNAL, 1993, 12 (11) : 4269 - 4278
  • [10] CLONING OF THE GENE ENCODING THE YEAST PROTEIN BTF1Y, WHICH CAN SUBSTITUTE FOR THE HUMAN TATA BOX-BINDING FACTOR
    CAVALLINI, B
    FAUS, I
    MATTHES, H
    CHIPOULET, JM
    WINSOR, B
    EGLY, JM
    CHAMBON, P
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (24) : 9803 - 9807