DIFFERENTIAL MODIFICATION OF THE REWARDING EFFECTS OF METHAMPHETAMINE AND COCAINE BY OPIOIDS AND ANTIHISTAMINES

被引：75

作者：

MASUKAWA, Y

SUZUKI, T

MISAWA, M

机构：

[1] HOSHI UNIV,SCH PHARM,DEPT PHARMACOL,SHINAGAWA KU,TOKYO 142,JAPAN

[2] LEDERLE LTD,DEPT PHARMACOL,BIOL RES LABS,SAITAMA 353,JAPAN

来源：

PSYCHOPHARMACOLOGY | 1993年 / 111卷 / 02期

关键词：

METHAMPHETAMINE; COCAINE; OPIOIDS; ANTIHISTAMINES; PLACE PREFERENCE; DRUG INTERACTION; RAT;

D O I：

10.1007/BF02245515

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We previously reported that the reinforcing effects of opioids are enhanced in combination with antihistamines. In the present study, effects of opioids and antihistamines on the reinforcing effects of psychostimulants such as methamphetamine and cocaine were investigated by utilizing the conditioned place preference procedure in rats. The place preference induced by methamphetamine was enhanced in combination with either morphine or chlorpheniramine, which produced additive and potentiative effects, respectively. In contrast, although the preference for cocaine was also enhanced by combination with these two drugs, morphine caused a potentiative effect and chlorpheniramine an additive one. In other words, the reinforcing effect of methamphetamine was differentially enhanced by opioids and antihistamines as compared to that of cocaine. These results suggest that the mechanism of reinforcing effect of methamphetamine is different from that of cocaine, resembling rather those of opioids.

引用

页码：139 / 143

页数：5

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