DISSOCIATION AND COMPLEXATION OF FLUOROQUINOLONE ANALOGS

被引:64
作者
LEE, DS
HAN, HJ
KIM, K
PARK, WB
CHO, JK
KIM, JH
机构
[1] NATL INST SAFETY RES,SEOUL 122020,SOUTH KOREA
[2] UNIV GEORGIA,DEPT PHARM,ATHENS,GA 30601
关键词
FLUOROQUINOLONE ANTIBIOTICS; DISSOCIATION CONSTANT; FORMATION CONSTANT; FLUOROQUINOLONE IRON(III) COMPLEX; SPECTROPHOTOMETRY;
D O I
10.1016/0731-7085(94)90025-6
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The dissociation and the complexation behaviours of four fluoroquinolone antibiotics have been studied. The acid dissociation constants of ciprofloxacin, enoxacin, norfloxacin and ofloxacin were determined by conventional potentiometric and conductometric techniques. Increasing the Hammett substituent constant, the pK(a) values were decreased. The absorption of fluoroquinolones in the intestinal tract are probably transported by pH-dependent mechanisms. Formation constants of the iron(III) complexes (1:1) of the fluoroquinolone analogues were determined by spectrophotometry. The optimum pH for complexation was 3.80.
引用
收藏
页码:157 / 164
页数:8
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