DNA GYRASE MUTATIONS IN QUINOLONE-RESISTANT CLINICAL ISOLATES OF NEISSERIA-GONORRHOEAE

被引：73

作者：

DEGUCHI, T

YASUDA, M

ASANO, M

TADA, K

IWATA, H

KOMEDA, H

EZAKI, T

SAITO, I

KAWADA, Y

机构：

[1] GIFU UNIV,SCH MED,DEPT UROL,GIFU 500,JAPAN

[2] GIFU UNIV,SCH MED,DEPT MICROBIOL,GIFU 500,JAPAN

[3] TOKYO KYOSAI HOSP,DEPT UROL,TOKYO 153,JAPAN

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1995年 / 39卷 / 02期

关键词：

D O I：

10.1128/AAC.39.2.561

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Eight quinolone-resistant clinical isolates of Neisseria gonorrhoeae were shown to carry mutations in their GyrA proteins. Six isolates had a single amino acid change of serine to phenylalanine at the position corresponding to Ser-83 in Escherichia coli. In addition to the change of serine to phenylalanine, two isolates had another change of aspartic acid to asparagine at the position corresponding to Asp-87 in E. coli.

引用

页码：561 / 563

页数：3

共 22 条

[1] [Anonymous], 1993, M7A3 NAT COMM CLIN L
[2] ORAL CIPROFLOXACIN VERSUS CEFTRIAXONE FOR THE TREATMENT OF URETHRITIS FROM RESISTANT NEISSERIA-GONORRHOEAE IN ZAMBIA
BRYAN, JP
HIRA, SK
BRADY, W
LUO, N
MWALE, C
MPOKO, G
KRIEG, R
SIWIWALIONDO, E
REICHART, C
WATERS, C
PERINE, PL
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1990, 34 (05) : 819 - 822
[3] CLONING AND CHARACTERIZATION OF A DNA GYRASE-A GENE FROM ESCHERICHIA-COLI THAT CONFERS CLINICAL RESISTANCE TO 4-QUINOLONES
CULLEN, ME
WYKE, AW
KURODA, R
FISHER, LM
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (06) : 886 - 894
[4] DECREASED SUSCEPTIBILITY OF NEISSERIA-GONORRHOEAE TO CIPROFLOXACIN
GRANSDEN, WR
WARREN, CA
PHILLIPS, I
HODGES, M
BARLOW, D
[J]. LANCET, 1990, 335 (8680) : 51 - 51
[5] NOVEL QUINOLONE RESISTANCE MUTATIONS OF THE ESCHERICHIA-COLI DNA GYRASE A-PROTEIN - ENZYMATIC ANALYSIS OF THE MUTANT PROTEINS
HALLETT, P
MAXWELL, A
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1991, 35 (02) : 335 - 340
[6] MUTATIONS IN THE GYRA GENE OF A HIGHLY FLUOROQUINOLONE-RESISTANT CLINICAL ISOLATE OF ESCHERICHIA-COLI
HEISIG, P
SCHEDLETZKY, H
FALKENSTEINPAUL, H
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (04) : 696 - 701
[7] HOOPER DC, 1991, NEW ENGL J MED, V324, P384, DOI 10.1056/NEJM199102073240606
[8] HOROWITZ DS, 1987, J BIOL CHEM, V262, P5339
[9] CIPROFLOXACIN RESISTANCE IN GONOCOCCI
JEPHCOTT, AE
TURNER, A
[J]. LANCET, 1990, 335 (8682) : 165 - 165
[10] NUCLEOTIDE-SEQUENCE OF THE STAPHYLOCOCCUS-AUREUS GYRB-GYRA LOCUS ENCODING THE DNA GYRASE A-PROTEIN AND B-PROTEIN
MARGERRISON, EEC
HOPEWELL, R
FISHER, LM
[J]. JOURNAL OF BACTERIOLOGY, 1992, 174 (05) : 1596 - 1603

← 1 2 3 →