SUPPRESSION OF MALIGNANCY BY CELL FUSION

被引：567

作者：

HARRIS, H

MILLER, OJ

KLEIN, G

WORST, P

TACHIBANA, T

机构：

[1] Department of Tumor Biology, Karolinska Institutet

来源：

NATURE | 1969年 / 223卷 / 5204期

关键词：

D O I：

10.1038/223363a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Malignancy can be suppressed when malignant cells are fused with certain non-malignant ones. The hybrid cells derived from such fusions give rise to segregants in which a loss of chromosomes is associated with reversion to malignancy. The expression of histo-compatibility antigens can also be suppressed when cells bearing these antigens are fused with others that express them poorly. © 1969 Nature Publishing Group.

引用

页码：363 / +

页数：1

共 27 条

[1] BARSKI G, 1962, J NATL CANCER I, V28, P801
[2] BURDETTE WJ, 1966, VIRUSES INDUCING ED, P323
[3] PROPERTIES OF HYBRIDS BETWEEN POLYOMA-TRANSFORMED AND NORMAL MOUSE CELLS
DEFENDI, V
EPHRUSSI, B
KOPROWSKI, H
YOSHIDA, MC
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1967, 57 (02) : 299 - +
[4] EXPRESSION OF POLYOMA-INDUCED CELLULAR ANTIGEN(S) IN HYBRID CELLS
DEFENDI, V
EPHRUSSI, B
KOPROWSKI, H
[J]. NATURE, 1964, 203 (494) : 495 - &
[5] RECOMBINATION AND SEGREGATION IN SOMATIC CELL HYBRIDS
ENGEL, E
MCGEE, BJ
HARRIS, H
[J]. NATURE, 1969, 223 (5202) : 152 - &
[6] ENGEL E, IN PRESS
[7] FAGRAEUS A, 1965, IMMUNOLOGY, V9, P161
[8] GORER PA, 1956, TRANSPLAN B, V3, P142
[9] HYBRID CELLS DERIVED FROM MOUSE AND MAN - ARTIFICIAL HETEROKARYONS OF MAMMALIAN CELLS FROM DIFFERENT SPECIES
HARRIS, H
WATKINS, JF
[J]. NATURE, 1965, 205 (4972) : 640 - &
[10] HARRIS H, 1966, J CELL SCI, V1, P1

← 1 2 3 →