HYDRATION OF CIS-EPOXYMETHYL AND TRANS-EPOXYMETHYL STEARATES BY THE CYTOSOLIC EPOXIDE HYDRASE OF MOUSE-LIVER

被引：84

作者：

GILL, SS ^{[1
]}

HAMMOCK, BD ^{[1
]}

机构：

[1] UNIV CALIF RIVERSIDE,DEPT ENTOMOL,DIV TOXICOL & PHYSIOL,RIVERSIDE,CA 92521

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 89卷 / 03期

关键词：

D O I：

10.1016/0006-291X(79)91872-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Man is exposed to epoxides of fatty acids from a number of sources, yet their degradative metabolism is not well understood. In mouse liver the 100,000 g supernatant or the cytosolic fraction is the most active fraction in hydrating cis- and trans-epoxymethyl stearates with the oxirane ring opening in a trans manner to give the corresponding threo and erythro diols, respectively. Hydration was also observed in the microsomal, nuclei and cell debris, and mitochondrial fractions in decreasing order of specific activity. © 1979.

引用

页码：965 / 971

页数：7

共 28 条

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