Carrier Design: Biodistribution of Branched Polypeptides with a Poly(L-lysine) Backbone

被引：27

作者：

Clegg, J. A. ^{[1
]}

Hudecz, F. ^{[2
]}

Mezoe, G. ^{[2
]}

Pimm, M. V. ^{[1
]}

Szekerke, M. ^{[2
]}

Baldwin, R. W. ^{[1
]}

机构：

[1] Univ Nottingham, Canc Res Campaign Labs, Nottingham NG7 2RD, England

[2] Eotvos Lorand Univ, Hungarian Acad Sci, Res Grp Peptide Chem, H-1518 Budapest 112, Hungary

来源：

BIOCONJUGATE CHEMISTRY | 1990年 / 1卷 / 06期

关键词：

D O I：

10.1021/bc00006a009

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The biodistribution has been examined in mice of a range of synthetic branched polypeptides which are based on a polylysine backbone but which differ in ionic charge, side-chain structure, and molecular size. Polycationic polypeptides, regardless of their size or primary structure at the branches, were cleared rapidly from the circulation, the liver being the major site of clearance. Polypeptides with glutamic acid in the side chain, which would be amphoteric under physiological conditions, showed a significantly prolonged blood survival, and this was seen with polypeptides in the range of molecular weights of 46 000 up to 213 000. Such polypeptides provide a useful system with which to investigate the effect of structural parameters on the pharmacokinetic properties of carrier molecules and would allow the selection of candidate carriers for a variety of uses.

引用

页码：425 / 430

页数：6

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