CHEMOMETRIC OPTIMIZATION OF THE RUTHENIUM CARBONYL CATALYZED CYCLIZATION OF 2-NITROSTILBENE TO 2-PHENYLINDOLE

被引:27
作者
CROTTI, C
CENINI, S
TODESCHINI, R
TOLLARI, S
机构
[1] DIPARTIMENTO CHIM INORGAN & MET ORGAN,VIA VENEZIAN 21,I-20133 MILAN,ITALY
[2] CNR CTR,I-20133 MILAN,ITALY
[3] DIPARTIMENTO CHIM FIS & ELETTROCHIM,I-20133 MILAN,ITALY
[4] DIPARTIMENTO CHIM ORGAN & IND,I-20133 MILAN,ITALY
来源
JOURNAL OF THE CHEMICAL SOCIETY-FARADAY TRANSACTIONS | 1991年 / 87卷 / 17期
关键词
D O I
10.1039/ft9918702811
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
A chemometric optimization of the Ru3(CO)12 catalysed deoxygenation of 2-nitrostilbene to 2-phenylindole was carried out. The effects of temperature, CO pressure, amounts of catalyst and substrate on conversion and selectivity were examined by factorial design/response surface methods. The conversion was found to increase on increasing the temperature and decreasing the CO pressure, it assumed a minimum value for medium amounts of catalyst and was almost independent of the amount of substrate. These results were also confirmed using a learning system and were used to develop a mechanism for the reaction. The data suggest two different mechanisms: one based on a Ru(CO)5 catalysed process and another one based on a Ru3(CO)12 catalysed process, which are first and zero order with respect to the substrate, respectively.
引用
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页码:2811 / 2820
页数:10
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