DELAYED-TYPE HYPERSENSITIVITY RESPONSE TO THE HUMAN PAPILLOMAVIRUS TYPE-16 E7 PROTEIN IN A MOUSE MODEL

被引：34

作者：

MCLEAN, CS ^{[1
]}

STERLING, JS ^{[1
]}

MOWAT, J ^{[1
]}

NASH, AA ^{[1
]}

STANLEY, MA ^{[1
]}

机构：

[1] UNIV CAMBRIDGE, DEPT PATHOL, CAMBRIDGE CB2 1QP, ENGLAND

来源：

JOURNAL OF GENERAL VIROLOGY | 1993年 / 74卷

关键词：

D O I：

10.1099/0022-1317-74-2-239

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

To study the immune response to human papillomavirus type 16, a mouse model was developed using a mouse keratinocyte cell line expressing the E7 protein. This line was grafted onto syngeneic mice to form a differentiated epithelium, thus closely mimicking the natural infection. A delayed-type hypersensitiviy response could be demonstrated after intradermal challenge with a vaccinia virus recombinant expressing the E7 protein. This response appeared to be specific for the E7 polypeptide and was mediated by CD4+ cells.

引用

页码：239 / 245

页数：7

共 43 条

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