GROWTH INHIBITORY EFFECTS OF BIOFLAVONOIDS AND RELATED-COMPOUNDS ON HUMAN LEUKEMIC CEM-C1 AND CEM-C7 CELLS

被引：60

作者：

POST, JFM ^{[1
]}

VARMA, RS ^{[1
]}

机构：

[1] BAYLOR COLL MED, CTR BIOTECHNOL, THE WOODLANDS, TX 77381 USA

来源：

CANCER LETTERS | 1992年 / 67卷 / 2-3期

关键词：

LUTEOLIN; FLAVONOIDS; CHALCONES; GROWTH INHIBITION; P-31-NMR; C-13-NMR;

D O I：

10.1016/0304-3835(92)90145-L

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Seven compounds, which included some naturally occurring dietary substances, were tested for their inhibitory effects on growth and metabolism of human leukemic CEM-C1 and CEM-C7 cell lines. Among the active compounds the naturally occurring dietary constituents were found to be the most active. The strongest inhibitory effects were observed with 3',4',5,7-tetrahydroxy-flavone (luteolin) and 4,4'-dihydroxychalcone. P-31-NMR spectra of cells incubated for 24 h with 30 muM of either of these compounds show complete ATP depletion. Also glucose uptake by the cells as measured by C-13-NMR is completely inhibited by these compounds. These results may be relevant to the tumor suppressing activity of bioflavonoids and the role of these compounds in chemoprevention.

引用

页码：207 / 213

页数：7

共 25 条

[1]

ADLERCREUTZ H, 1984, GASTROENTEROLOGY, V86, P761

[2] ISOLATION OF A DIMERIC 9-PHENYLPHENALENONE FROM LACHNANTHES-TINCTORIA [J].

EDWARDS, JM ;

HITE, GJ .

JOURNAL OF NATURAL PRODUCTS, 1979, 42 (06) :681-681

[3]

FOLEY GE, 1965, CANCER, V18, P522, DOI 10.1002/1097-0142(196504)18:4<522::AID-CNCR2820180418>3.0.CO

[4]

2-J

[5]

HAENSZEL W, 1980, JNCI-J NATL CANCER I, V64, P17

[6] FLAVONOIDS, A CLASS OF NATURAL-PRODUCTS OF HIGH PHARMACOLOGICAL POTENCY [J].

HAVSTEEN, B .

BIOCHEMICAL PHARMACOLOGY, 1983, 32 (07) :1141-1148

[7] INHIBITORY EFFECT OF QUERCETIN ON THE SYNTHESIS OF A POSSIBLY CELL-CYCLE-RELATED 17-KDA PROTEIN, IN HUMAN COLON CANCER-CELLS [J].

HOSOKAWA, N ;

HOSOKAWA, Y ;

SAKAI, T ;

YOSHIDA, M ;

MARUI, N ;

NISHINO, H ;

KAWAI, K ;

AOIKE, A .

INTERNATIONAL JOURNAL OF CANCER, 1990, 45 (06) :1119-1124

[8] THERMAL REARRANGEMENT OF 2'-HYDROXYCHALKONE HYDRAZONE AND FLAVANONE HYDRAZONE DERIVATIVES [J].

KALLAY, F ;

JANZSO, G ;

KOCZOR, I .

TETRAHEDRON, 1965, 21 (11) :3037-&

[9] ANTIPROLIFERATIVE EFFECTS OF CITRUS FLAVONOIDS ON A HUMAN SQUAMOUS-CELL CARCINOMA INVITRO [J].

KANDASWAMI, C ;

PERKINS, E ;

SOLONIUK, DS ;

DRZEWIECKI, G ;

MIDDLETON, E .

CANCER LETTERS, 1991, 56 (02) :147-152

[10] COMPUTER AUTOMATED STRUCTURE EVALUATION (CASE) OF FLAVONOIDS AS LARVAL GROWTH-INHIBITORS [J].

KLOPMAN, G ;

VENEGAS, RE .

PURE AND APPLIED CHEMISTRY, 1988, 60 (02) :265-270

← 1 2 3 →