SYNTHESIS AND ANTIACETYLCHOLINESTERASE ACTIVITY OF 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE HYDROCHLORIDE (E2020) AND RELATED-COMPOUNDS

被引：73

作者：

SUGIMOTO, H

IIMURA, Y

YAMANISHI, Y

YAMATSU, K

机构：

[1] Tsukuba Research Laboratories, Eisai Co., Ltd., Tsukuba-shi, Ibaraki, 300-26, 1-3

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(00)80547-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：871 / 876

页数：6

共 6 条

[1] QSAR ANALYSES OF THE SUBSTITUTED INDANONE AND BENZYLPIPERIDINE RINGS OF A SERIES OF INDANONE BENZYLPIPERIDINE INHIBITORS OF ACETYLCHOLINESTERASE [J].

CARDOZO, MG ;

IIMURA, Y ;

SUGIMOTO, H ;

YAMANISHI, Y ;

HOPFINGER, AJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (03) :584-589

[2] CONFORMATIONAL-ANALYSES AND MOLECULAR-SHAPE COMPARISONS OF A SERIES OF INDANONE BENZYLPIPERIDINE INHIBITORS OF ACETYLCHOLINESTERASE [J].

CARDOZO, MG ;

KAWAI, T ;

IMURA, Y ;

SUGIMOTO, H ;

YAMANISHI, Y ;

HOPFINGER, AJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (03) :590-601

[3] A NEW AND RAPID COLORIMETRIC DETERMINATION OF ACETYLCHOLINESTERASE ACTIVITY [J].

ELLMAN, GL ;

COURTNEY, KD ;

ANDRES, V ;

FEATHERSTONE, RM .

BIOCHEMICAL PHARMACOLOGY, 1961, 7 (02) :88-&

[4] SYNTHESIS OF 1-BENZYL-4-[(5,6-DIMETHOXY[2-C-14]-1-INDANON)-2-YL]-METHYLPIPERIDINE HYDROCHLORIDE (E2020-C-14) [J].

IIMURA, Y ;

MISHIMA, M ;

SUGIMOTO, H .

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 1989, 27 (07) :835-839

[5] NOVEL PIPERIDINE-DERIVATIVES - SYNTHESIS AND ANTIACETYLCHOLINESTERASE ACTIVITY OF 1-BENZYL-4-[2-(N-BENZOYLAMINO)ETHYL]PIPERIDINE DERIVATIVES [J].

SUGIMOTO, H ;

TSUCHIYA, Y ;

SUGUMI, H ;

HIGURASHI, K ;

KARIBE, N ;

IIMURA, Y ;

SASAKI, A ;

KAWAKAMI, Y ;

NAKAMURA, T ;

ARAKI, S ;

YAMANISHI, Y ;

YAMATSU, K .

JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (07) :1880-1887

[6]

SUGIMOTO H, 1989, 7TH FRENCH JAP S MED, P78

← 1 →