FECAL CALPROTECTIN - A NOVEL TEST FOR THE DIAGNOSIS OF COLORECTAL-CANCER

被引：130

作者：

ROSETH, AG

KRISTINSSON, J

FAGERHOL, MK

SCHJONSBY, H

AADLAND, E

NYGAARD, K

ROALD, B

机构：

[1] AKER UNIV HOSP,DEPT SURG,N-0514 OSLO,NORWAY

[2] ULLEVAL UNIV HOSP,BLOOD BANK,OSLO,NORWAY

[3] ULLEVAL UNIV HOSP,DEPT PATHOL,OSLO,NORWAY

[4] ULLEVAL UNIV HOSP,DEPT IMMUNOL,OSLO,NORWAY

来源：

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY | 1993年 / 28卷 / 12期

关键词：

COLORECTAL ADENOMAS; COLORECTAL CANCER; FECAL CALPROTECTIN; GASTRIC CANCER;

D O I：

10.3109/00365529309098312

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Calprotectin, a prominent cytosol protein in neutrophil granulocytes, was present in increased concentrations in stools from 50 of 53 patients with colorectal cancer, 32 of 40 patients with colorectal polyps, and all of 18 patients with gastric cancer. After radical surgery, faecal calprotectin levels reverted to the normal range in all but one patient with colorectal cancer. Calprotectin determinations are simplified by the stability of this protein in stools. Reliable estimates can be obtained in samples of only 5 g. On the basis of data from the literature, the test for calprotectin seems better than that for occult blood for the detection of gastrointestinal neoplasms.

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页码：1073 / 1076

页数：4

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