LITHIUM INCREASES SUSCEPTIBILITY OF MUSCLE GLUCOSE-TRANSPORT TO STIMULATION BY VARIOUS AGENTS

被引:52
作者
TABATA, I [1 ]
SCHLUTER, J [1 ]
GULVE, EA [1 ]
HOLLOSZY, JO [1 ]
机构
[1] WASHINGTON UNIV,SCH MED,DEPT MED,ST LOUIS,MO 63110
关键词
D O I
10.2337/diabetes.43.7.903
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Lithium is thought to have an insulin-like effect on glucose transport and metabolism in skeletal muscle and adipocytes. However, we found that lithium had only a minimal effect on basal glucose transport activity in rat epitrochlearis muscles. Instead, lithium markedly increased the sensitivity of glucose transport to insulin, so that the increase in glucose transport activity induced by 300 pM insulin was similar to 2.5-fold greater in the presence of lithium than in its absence. Lithium also caused a modest increase in insulin responsiveness. This enhancement of the susceptibility of the glucose transport process to stimulation was not limited to insulin, because lithium induced increases in the susceptibility of glucose transport to stimulation by contractile activity, hypoxia, a phorbol ester, and phospholipase C. Lithium also blunted the activation of glycogen phosphorylase by epinephrine. These effects were not mediated by inhibition of adenylate cyclase, because neither basal- nor epinephrine-stimulated muscle cAMP concentration was affected by Lithium treatment. The effects of lithium on glucose transport and metabolism in skeletal muscle are strikingly similar to the persistent effects of exercise. These results support the possibility that lithium might be useful in the treatment of insulin resistance in patients with noninsulin-dependent diabetes mellitus.
引用
收藏
页码:903 / 907
页数:5
相关论文
共 37 条
[1]  
BERGSTROM J, 1972, SCAND J CLIN LAB INV, V29, P231, DOI 10.3109/00365517209081080
[2]   MUSCLE GLYCOGEN SYNTHESIS AFTER EXERCISE - AN ENHANCING FACTOR LOCALIZED TO MUSCLE CELLS IN MAN [J].
BERGSTROM, J ;
HULTMAN, E .
NATURE, 1966, 210 (5033) :309-+
[3]   INFLUENCE OF LI PLUS ON GLUCOSE METABOLISM IN RATS + RABBITS [J].
BHATTACHARYA, G .
BIOCHIMICA ET BIOPHYSICA ACTA, 1964, 93 (03) :644-&
[4]   DUAL EFFECT OF ADRENALIN ON SUGAR-TRANSPORT IN RAT DIAPHRAGM MUSCLE [J].
BIHLER, I ;
SAWH, PC ;
SLOAN, IG .
BIOCHIMICA ET BIOPHYSICA ACTA, 1978, 510 (02) :349-360
[5]   STIMULATION OF GLUCOSE-TRANSPORT IN SKELETAL-MUSCLE BY HYPOXIA [J].
CARTEE, GD ;
DOUEN, AG ;
RAMLAL, T ;
KLIP, A ;
HOLLOSZY, JO .
JOURNAL OF APPLIED PHYSIOLOGY, 1991, 70 (04) :1593-1600
[6]   EXERCISE INCREASES SUSCEPTIBILITY OF MUSCLE GLUCOSE-TRANSPORT TO ACTIVATION BY VARIOUS STIMULI [J].
CARTEE, GD ;
HOLLOSZY, JO .
AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 258 (02) :E390-E393
[7]   PROLONGED INCREASE IN INSULIN-STIMULATED GLUCOSE-TRANSPORT IN MUSCLE AFTER EXERCISE [J].
CARTEE, GD ;
YOUNG, DA ;
SLEEPER, MD ;
ZIERATH, J ;
WALLBERGHENRIKSSON, H ;
HOLLOSZY, JO .
AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 256 (04) :E494-E499
[8]  
CHENG K, 1983, MOL CELL BIOCHEM, V56, P183
[9]  
CHENG K, 1983, MOL CELL BIOCHEM, V56, P177