IMINIUM SALT BENZOCHLORINS - STRUCTURE-ACTIVITY RELATIONSHIP STUDIES

被引：12

作者：

SKALKOS, D

HAMPTON, JA

KECK, RW

WAGONER, M

SELMAN, SH

机构：

[1] UNIV TOLEDO, DEPT CHEM, TOLEDO, OH 43606 USA

[2] MED COLL OHIO, DEPT UROL, TOLEDO, OH 43699 USA

[3] MED COLL OHIO, DEPT PATHOL, TOLEDO, OH 43699 USA

来源：

PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1994年 / 59卷 / 02期

关键词：

D O I：

10.1111/j.1751-1097.1994.tb05019.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An iminium salt of copper(II) octaethylbenzochlorin (CDS1) is an effective new photosensitizer despite the fact that it does not produce singlet oxygen, does not fluoresce and the triplet state lifetime can only be less than 20 ns. A number of octaethylbenzochlorin derivatives were synthesized in order to determine the structural component(s) that is(are) responsible for the photodynamic action of these new photosensitizers. Studies utilizing the N-(4-[5-nitro-2-furyl]-2-thiazolyl)formamide-induced urothelial tumor revealed that the coexistence of the copper inside the aromatic ring and the iminium group at the meso position are required for the photodynamic effect.

引用

页码：175 / 181

页数：7

共 24 条

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