MOLECULAR-IDENTIFICATION OF AN IGE-DEPENDENT HISTAMINE-RELEASING FACTOR

被引：306

作者：

MACDONALD, SM

RAFNAR, T

LANGDON, J

LICHTENSTEIN, LM

机构：

[1] Department of Medicine, Johns Hopkins University School of Medicine, Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224

来源：

SCIENCE | 1995年 / 269卷 / 5224期

关键词：

D O I：

10.1126/science.7542803

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

An immunoglobulin E (IgE)-dependent histamine-releasing factor (HRF) produced by lymphocytes of atopic children and present in biological fluids of allergic patients has been identified and purified. Amino-terminal sequencing revealed extensive homology to a mouse protein, p21, and its human homolog, p23. Both recombinant proteins caused histamine release from the human basophils of a subpopulation of donors, and this release was dependent on IgE. Polyclonal antibodies recognized and removed the biological activity of recombinant and native HRF. HRF identifies a heterogeneity of IgE and is believed to play a prominent role in chronic allergic disease processes.

引用

页码：688 / 690

页数：3

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