RS-100235 - A HIGH-AFFINITY 5-HT4 RECEPTOR ANTAGONIST

被引：17

作者：

CLARK, RD ^{[1
]}

JAHANGIR, A ^{[1
]}

FLIPPIN, LA ^{[1
]}

LANGSTON, JA ^{[1
]}

LEUNG, E ^{[1
]}

BONHAUS, DW ^{[1
]}

WONG, EHF ^{[1
]}

JOHNSON, LG ^{[1
]}

EGLEN, RM ^{[1
]}

机构：

[1] SYNTEX INC,INST PHARMACOL,PALO ALTO,CA 94304

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 18期

关键词：

D O I：

10.1016/0960-894X(95)00358-Z

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The 1,4-benzodioxanyl ketone 14 (RS-100235) was found to be high affinity 5-HT4 antagonist with potent in vivo activity and a sustained duration of action in the anesthetized pig.

引用

页码：2119 / 2122

页数：4

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