High prospective fetal loss rate in untreated pregnancies of women with recurrent miscarriage and antiphospholipid antibodies

被引:200
作者
Rai, RS
Clifford, K
Cohen, H
Regan, L
机构
[1] ST MARYS HOSP,SCH MED,DEPT OBSTET & GYNAECOL,LONDON W2 1PG,ENGLAND
[2] ST MARYS HOSP,SCH MED,DEPT HAEMATOL,LONDON W2 1PG,ENGLAND
关键词
antiphospholipid antibodies; pregnancy; prospective study; recurrent miscarriage;
D O I
10.1093/oxfordjournals.humrep.a135907
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Antiphospholipid antibodies (APA), lupus anticoagulant (LA) and/or anticardiolipin antibodies (ACA), are associated with thrombosis and recurrent miscarriage, We studied the outcome of 20 pregnancies in women (median age 32 years; range 23-41) with APA (14 LA positive; three immunoglobulin (Ig) G ACA positive; two IgM ACA positive and one LA and IgG ACA positive) and history of recurrent miscarriage (median 4; range 3-11) who declined pharmacological treatment in their next pregnancy. Comparison was made with a cohort of 100 consecutive women (median age 33 years; range 23-44) with recurrent miscarriage (median 4; range 3-10), in whom no underlying cause to account for their pregnancy losses was found, Of the 20 women with APA, 18 (90%) miscarried compared to 34 of the 100 women (34%) with normal investigations (P < 0.001), The majority (94%) of miscarriages in women with APA occurred in the first trimester, Fetal heart activity was seen prior to fetal death in 86% of women with APA compared to 43% of women with normal investigations (P < 0.01), The first trimester loss of embryonic pregnancies is the most common type of miscarriage in women with BPA, This may be a result of defective implantation and subsequent placentation.
引用
收藏
页码:3301 / 3304
页数:4
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