METABOLIC EFFECTS OF AZASERINE IN RAT BRAIN

被引：6

作者：

HELD, I

WELLS, W

KOENIG, H

机构：

[1] Neurology Service, Veterans Administration Research Hospital, Chicago, Illinois

[2] Departments of Biochemistry and of Neurology and Psychiatry, Northwestern University Medical School, Chicago, Illinois

来源：

JOURNAL OF NEUROCHEMISTRY | 1969年 / 16卷 / 04期

关键词：

D O I：

10.1111/j.1471-4159.1969.tb06852.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The de novo biosynthesis of purine nucleotides in rat brain was markedly and rapidly inhibited by intracerebral injections of azaserine. After 48 hr the animals became paraplegic. The biosynthesis of purine and pyrimidine nucleotides, RNA and protein was investigated by radioactive tracer studies over a 4‐day period in an attempt to correlate the azaserine‐induced, metabolic lesions found in rat brain and the manifested, peripheral, neurological disturbance. Copyright © 1969, Wiley Blackwell. All rights reserved

引用

页码：537 / &

共 19 条

[1] SOME OBSERVATIONS ON INCORPORATION OF PRECURSORS INTO RIBONUCLEIC ACID OF RAT BRAIN [J].