IRON-DEPENDENT HYDROXYL RADICAL FORMATION AND DNA DAMAGE FROM A NOVEL METABOLITE OF THE CLINICALLY ACTIVE ANTITUMOR DRUG VP-16

被引:37
作者
SINHA, BK [1 ]
ELIOT, HM [1 ]
KALAYANARAMAN, B [1 ]
机构
[1] MED COLL WISCONSIN,DEPT RADIOL,MILWAUKEE,WI 53226
关键词
D O I
10.1016/0014-5793(88)80906-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:240 / 244
页数:5
相关论文
共 20 条
[1]   HOW CAN IRON SALTS MEDIATE THE DEGRADATION OF NUCLEOS(T)IDES BY ELLIPTINIUM ACETATE VIA FREE-RADICALS [J].
DUGUE, B ;
MEUNIER, B .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1985, 133 (01) :15-22
[2]   OXIDATIVE DESTRUCTION OF DNA BY THE ADRIAMYCIN IRON COMPLEX [J].
ELIOT, H ;
GIANNI, L ;
MYERS, C .
BIOCHEMISTRY, 1984, 23 (05) :928-936
[3]   HYDROXYL FREE-RADICAL FORMATION FROM HYDROGEN-PEROXIDE BY FERROUS IRON NUCLEOTIDE COMPLEXES [J].
FLOYD, RA ;
LEWIS, CA .
BIOCHEMISTRY, 1983, 22 (11) :2645-2649
[4]   INVITRO METABOLISM OF ETOPOSIDE (VP-16-213) BY LIVER-MICROSOMES AND IRREVERSIBLE BINDING OF REACTIVE INTERMEDIATES TO MICROSOMAL PROTEINS [J].
HAIM, N ;
NEMEC, J ;
ROMAN, J ;
SINHA, BK .
BIOCHEMICAL PHARMACOLOGY, 1987, 36 (04) :527-536
[5]   PEROXIDATIVE FREE-RADICAL FORMATION AND O-DEMETHYLATION OF ETOPOSIDE(VP-16) AND TENIPOSIDE(VM-26) [J].
HAIM, N ;
ROMAN, J ;
NEMEC, J ;
SINHA, BK .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 135 (01) :215-220
[6]   EFFECT OF VP-16-213 ON INTRACELLULAR DEGRADATION OF DNA IN HELA-CELLS [J].
LOIKE, JD ;
HORWITZ, SB .
BIOCHEMISTRY, 1976, 15 (25) :5443-5448
[7]   COMPARISON OF CYTO-TOXICITY AND DNA BREAKAGE ACTIVITY OF CONGENERS OF PODOPHYLLOTOXIN INCLUDING VP16-213 AND VM26 - A QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP [J].
LONG, BH ;
MUSIAL, ST ;
BRATTAIN, MG .
BIOCHEMISTRY, 1984, 23 (06) :1183-1188
[8]  
MUINDI J, 1985, MOL PHARMACOL, V27, P356
[9]  
MYERS CE, 1987, J BIOL CHEM, V262, P11571
[10]  
ROW T, 1985, BIOCHEM PHARMACOL, V34, P2483