SISTER CHROMATID EXCHANGE IN CHROMOSOMES OF CATTLE (BOS-TAURUS)

被引:33
作者
BERARDINO, DD [1 ]
SHOFFNER, RN [1 ]
机构
[1] UNIV MINNESOTA,DEPT ANIM SCI,ST PAUL,MN 55108
关键词
D O I
10.3168/jds.S0022-0302(79)83299-3
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
Lymphocytes from clinically healthy Holstein animals (8 males and 23 females) were cultured in media containing 5-bromodeoxyuridine (10μg/ml) for two cycles of deoxyribonucleic acid replication (48 h). The exchange of sister chromatids per cell varied from 1 to 16 with a mean of 5.4 and a standard deviation of 2.1 in 603 differentially stained metaphase chromosome spreads. The major fraction of exchanges in the X chromosome were located in the region of the subcentromeric G negative bands ql and q2. When the cells were pulse labeled with tritium labeled thymidine (1μCi/ml) for the last 6 h of the cell cycle, the rate of exchange was higher in the late replicating X chromosome (facultative hetero-chromatin) in comparison to its homologue (active X). This study characterizes the yield of sister chromatid exchange in lymphocytes exposed to a given amount of 5-bromodeoxyuridine in a population of normal individuals so that it may be used as a standard for 1) a diagnostic tool in pathological conditions and 2) as an assay of chromosome stability in relation to environmental hazards. © 1979, American Dairy Science Association. All rights reserved.
引用
收藏
页码:627 / 632
页数:6
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