RECA-DEPENDENT INCREASED PRECISE EXCISION OF TN10 IN SALMONELLA-TYPHIMURIUM

被引：11

作者：

LEVY, MS ^{[1
]}

POMPOSIELLO, P ^{[1
]}

NAGEL, R ^{[1
]}

机构：

[1] CEFYBO,SERRANO 665,RA-1414 BUENOS AIRES,ARGENTINA

来源：

MUTATION RESEARCH | 1991年 / 255卷 / 01期

关键词：

TN10 PRECISE EXCISION; UV; MITOMYCIN-C; RECA; UVRD AND TOP MUTANTS; DELETIONS; ESCHERICHIA-COLI PLASMID; POSITIVE SELECTION; DELETION FORMATION; MUTAGENESIS; DNA; GENE; TRANSPOSON; RECOMBINATION; MODULATION; MUTATIONS;

D O I：

10.1016/0921-8777(91)90022-H

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

UV irradiation induced the precise excision of Tn10 inserted in met, trp or srl in a Salmonella typhimurium strain; mitomycin C was also found to induce the frequency of precise excision of Tn10 from srl or met. Precise excision of Tn10 was not increased by either UV or mitomycin C in a recA mutant. Similarly, a recA mutant derived from a uvrD strain showed a drastic reduction in the high spontaneous levels of precise excision of Tn10 of this strain. These results indicate that recA is involved in the increased precise excision of Tn10. In contrast to point mutations excision of Tn10 was found to be UV inducible in a top mutant.

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页码：95 / 100

页数：6

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