T-CELL RECEPTOR-MEDIATED NEGATIVE SELECTION OF AUTOREACTIVE LYMPHOCYTE-T PRECURSORS OCCURS AFTER COMMITMENT TO THE CD4 OR CD8 LINEAGES

被引：203

作者：

GUIDOS, CJ ^{[1
]}

DANSKA, JS ^{[1
]}

FATHMAN, CG ^{[1
]}

WEISSMAN, IL ^{[1
]}

机构：

[1] STANFORD UNIV,MED CTR,SCH MED,DIV IMMUNOL & RHEUMATOL,STANFORD,CA 94305

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1990年 / 172卷 / 03期

关键词：

D O I：

10.1084/jem.172.3.835

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To identify the maturational stage(s) during which T cell receptor (TCR)-mediated positive and negative selection occurs, we followed the development of CD4+8 − and CD4− 8+ T cells from TCRlo CD4+8+ thymic blasts in the presence of different positive and negative selecting (major histocompatibility complex or Mls) elements. We describe novel lineage-committed transitional intermediates that are TCRmed CD4+8lo or TCRmed CD4+8lo, and that show evidence of having been positively selected. Furthermore, negative selection is not evident until after cells have attained one of the TCRmed transitional phenotypes. Accordingly, we propose that negative selection in normal mice occurs only after TCRlo CD4+8+ precursors have been positively selected into either the CD4 or CD8 lineage. © 1990, Rockefeller University Press., All rights reserved.

引用

页码：835 / 845

页数：11

共 47 条

[1] EARLY EVENTS IN T-CELL MATURATION [J].

ADKINS, B ;

MUELLER, C ;

OKADA, CY ;

REICHERT, RA ;

WEISSMAN, IL ;

SPANGRUDE, GJ .

ANNUAL REVIEW OF IMMUNOLOGY, 1987, 5 :325-365

[2] POSITIVE SELECTION OF THE T-CELL REPERTOIRE - WHERE AND WHEN DOES IT OCCUR [J].

BENOIST, C ;

MATHIS, D .

CELL, 1989, 58 (06) :1027-1033

[3] PHENOTYPIC DIFFERENCES BETWEEN ALPHA-BETA-T-CELL VERSUS BETA-T-CELL RECEPTOR TRANSGENIC MICE UNDERGOING NEGATIVE SELECTION [J].

BERG, LJ ;

FAZEKAS DE ST GROTH, B ;

PULLEN, AM ;

DAVIS, MM .

NATURE, 1989, 340 (6234) :559-562

[4] ANTIGEN MHC-SPECIFIC T-CELLS ARE PREFERENTIALLY EXPORTED FROM THE THYMUS IN THE PRESENCE OF THEIR MHC LIGAND [J].

BERG, LJ ;

PULLEN, AM ;

FAZEKAS DE ST GROTH, B ;

MATHIS, D ;

BENOIST, C ;

DAVIS, MM .

CELL, 1989, 58 (06) :1035-1046

[5] POSITIVE SELECTION OF CD4+T CELLS MEDIATED BY MHC CLASS-II-BEARING STROMAL CELL IN THE THYMIC CORTEX [J].

BILL, J ;

PALMER, E .

NATURE, 1989, 341 (6243) :649-651

[6] THE MHC MOLECULE I-E IS NECESSARY BUT NOT SUFFICIENT FOR THE CLONAL DELETION OF V-BETA-11-BEARING T-CELLS [J].

BILL, J ;

KANAGAWA, O ;

WOODLAND, DL ;

PALMER, E .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 169 (04) :1405-1419

[7] INFLUENCE OF THE MAJOR HISTOCOMPATIBILITY COMPLEX ON POSITIVE THYMIC SELECTION OF V-BETA-17A+ T-CELLS [J].

BLACKMAN, MA ;

MARRACK, P ;

KAPPLER, J .

SCIENCE, 1989, 244 (4901) :214-217

[8] A 3RD-TYPE OF MURINE T-CELL RECEPTOR GENE [J].

CHIEN, Y ;

BECKER, DM ;

LINDSTEN, T ;

OKAMURA, M ;

COHEN, DI ;

DAVIS, MM .

NATURE, 1984, 312 (5989) :31-35

[9]

CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2

[10] THE PRESUMPTIVE CDR3 REGIONS OF BOTH T-CELL RECEPTOR ALPHA-CHAIN AND BETA-CHAIN DETERMINE T-CELL SPECIFICITY FOR MYOGLOBIN PEPTIDES [J].

DANSKA, JS ;

LIVINGSTONE, AM ;

PARAGAS, V ;

ISHIHARA, T ;

FATHMAN, CG .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (01) :27-33

← 1 2 3 4 5 →