A NEW ROUTE TO SECONDARY-AMINES FROM BIS-(ALKOXYMETHYL)ALKYLAMINES - THE ACTIVATION OF AN AMINOMETHYL GROUP AND PROTECTION OF THE PRODUCT BY THE SAME FUNCTIONAL-GROUP

被引：27

作者：

EARLE, MJ ^{[1
]}

FAIRHURST, RA ^{[1
]}

HEANEY, H ^{[1
]}

PAPAGEORGIOU, G ^{[1
]}

WILKINS, RF ^{[1
]}

机构：

[1] LOUGHBOROUGH UNIV TECHNOL,DEPT CHEM,LOUGHBOROUGH LE11 3TU,LEICS,ENGLAND

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 29期

关键词：

D O I：

10.1016/S0040-4039(00)97589-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of N,N-bis(alkoxymethyl)alkylamines with a variety of acidic reagents affords good yields of N-alkoxymethyl-N-alkylmethyleneiminium salts which react with trimethylsilyl enol ethers, and nucleophilic aromatic substrates to form protected secondary amines or tertiary amines by domino reactions; silyl ketene acetals afford tertiary amines only. © 1990.

引用

页码：4229 / 4232

页数：4

共 19 条

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