METHODS COMPARISON - CLONAZEPAM BY GAS CHROMATOGRAPHY-ELECTRON CAPTURE AND GAS CHROMATOGRAPHY-MASS SPECTROSCOPY

被引：12

作者：

WILSON, JM ^{[1
]}

FRIEL, PN ^{[1
]}

WILENSKY, AJ ^{[1
]}

RAISYS, VA ^{[1
]}

机构：

[1] UNIV WASHINGTON,HARBORVIEW MED CTR,DEPT LAB MED,SEATTLE,WA 98104

来源：

THERAPEUTIC DRUG MONITORING | 1979年 / 1卷 / 03期

关键词：

Chemical ionization selected ion monitoring; Clonazepam; Electron capture detector; Gas chromatography; Mass spectroscopy;

D O I：

10.1097/00007691-197901030-00012

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Clonazepam is an antiepileptic drug for which a number of analytical procedures have been presented, none of which have been subjected to comparison studies. We present two gas chromatographic (GC) methods involving distinct forms of detection for determining plasma or serum drug levels. Both methods involve simple extractions, common GC conditions, and routine data reduction. Both employ nitrazepam as an internal standard, require 1 ml of sample, and have a detection limit of 1 ng/ml. The two methods, GC-electron capture and GC-mass spectroscopy, are precise and accurate. Correlation of the two methods by paired sample analysis gave a regression equation of y = 0.988x - 0.14 (n = 30, r = 0.971, p <0.001). We suggest that either method is a reasonable alternative for the clinical laboratory with the proper instrumentation. © 1979 Raven Press, New York.

引用

页码：387 / 397

页数：11

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