DNA-GYRASE INHIBITION AND ANTIBACTERIAL ACTIVITY OF FLUOROQUINOLONES - INFLUENCE OF THE POSITION OF THE FLUORINE(S)

被引：7

作者：

CLAIREFOND, P ^{[1
]}

BOUZARD, D ^{[1
]}

LEDOUSSAL, B ^{[1
]}

CORONEOS, E ^{[1
]}

BAZILE, S ^{[1
]}

MOREAU, N ^{[1
]}

机构：

[1] CTR ETUD & RECH CHIM ORGAN APPL,CNRS,F-94320 THIAIS,FRANCE

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(00)80380-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of fluoro-quinolones was evaluated for antibacterial activity and DNA-gyrase inhibitory potency. The relative enhancement of the overall antibacterial activity resulting from C-6 or C-8 fluorine substituent was not accompanied with a major change of DNA-gyrase inhibitory potency.

引用

页码：643 / 646

页数：4

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