RELATIONSHIP OF NEURAL CELL-ADHESION MOLECULES (N-CAMS) WITH ADENYLATE-CYCLASE

被引：4

作者：

LIPKIN, VM

SURINA, EA

PETUKHOVA, GV

PETROV, VM

MIRZOEVA, SF

RAKITINA, TV

机构：

[1] Shemyakin Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117871 GSP Moscow, ul. Miklukho-Maklaya 16/10

来源：

FEBS LETTERS | 1992年 / 304卷 / 01期

关键词：

ADENYLATE CYCLASE; NEURAL CELL ADHESION MOLECULE;

D O I：

10.1016/0014-5793(92)80577-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bovine brain cDNA cloned earlier and attributed to calmodulin-independent adenylate cyclase encodes the neural cell adhesion molecule (N-CAM). The expression of N-CAM mRNA in Xenopus laevis oocytes increases their basal adenylate cyclase activity. Polyclonal antibodies against synthetic peptide A, VAENQQGKSKAAHFV (664-678 amino acid residues of bovine N-CAM), containing sequence AXXXXGKS which is homologous to the nucleotide-binding consensus sequence GXXXXGKS, inhibit the adenylate cyclase activity. A close relationship appears to exist between adenylate cyclase and N-CAM.

引用

页码：9 / 11

页数：3

共 16 条

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