RRR-ALPHA-TOCOPHERYL SUCCINATE INHIBITS PROLIFERATION AND ENHANCES SECRETION OF TRANSFORMING GROWTH-FACTOR-BETA (TGF-BETA) BY HUMAN BREAST-CANCER CELLS

被引：71

作者：

CHARPENTIER, A ^{[1
]}

GROVES, S ^{[1
]}

SIMMONSMENCHACA, M ^{[1
]}

TURLEY, J ^{[1
]}

ZHAO, BH ^{[1
]}

SANDERS, BG ^{[1
]}

KLINE, K ^{[1
]}

机构：

[1] UNIV TEXAS,DEPT ZOOL,AUSTIN,TX 78712

来源：

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 1993年 / 19卷 / 03期

关键词：

D O I：

10.1080/01635589309514254

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The RRR-alpha-tocopheryl succinate form of vitamin E inhibits the proliferation of estrogen receptor-positive and estrogen receptor-negative human breast cancer cell lines in a dose-dependent manner in vitro. Analyses of cell-conditioned medium from RRR-alpha-tocopheryl succinate growth-inhibited cells revealed the presence of a potent antiproliferative activity. Characterization of the antiproliferative activity as transforming growth factor-beta (TGF-beta) was established by 1) growth inhibition of the TGF-beta-responsive Mv1Lu-CCL-64 mink lung and murine CTLL-2 cell lines, 2) combination of physical characteristics including heat stability, acid stability, and Bio-Gel P-60 column chromatography elution profile, and 3) neutralization of the antiproliferative activity in the conditioned media by antibodies specific for TGF-beta.

引用

页码：225 / 239

页数：15

共 31 条

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