DELETION 9P22-PTER AND LOSS OF Y AS PRIMARY CHROMOSOME-ABNORMALITIES IN A SQUAMOUS-CELL CARCINOMA OF THE VOCAL CORD

被引：18

作者：

WORSHAM, MJ

BENNINGER, MJ

ZARBO, RJ

CAREY, TE

VANDYKE, DL

机构：

[1] HENRY FORD HOSP,2799 W GRAND BLVD,CFP-463,DETROIT,MI 48202

[2] CYTOGENET LAB,DETROIT,MI

[3] DEPT OTOLARYNGOL,DETROIT,MI

[4] DEPT PATHOL,DETROIT,MI

[5] UNIV MICHIGAN,CTR CANC,DEPT OTOLARYNGOL,DIV HEAD & NECK ONCOL,HEAD & NECK CANC BIOL LAB,ANN ARBOR,MI 48109

来源：

GENES CHROMOSOMES & CANCER | 1993年 / 6卷 / 01期

关键词：

D O I：

10.1002/gcc.2870060111

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Loss of distal 9p is a common genetic alteration in squamous cell carcinoma of the head and neck. A vocal cord lesion incorporating a carcinoma-in-situ and a focus of invasive carcinoma revealed loss of the Y chromosome and a 9p22 rearrangement with loss of 9p22-pter. Loss of 9p22-pter appears to be a primary autosomal abnormality in this squamous cell carcinoma.

引用

页码：58 / 60

页数：3

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